DISEASES

Disease-gene associations mined from literature

Literature associating ANAPC11 and milker's nodule

ANAPC11 [ENSP00000349957]

Anaphase-promoting complex subunit 11; Together with the cullin protein ANAPC2, constitutes the catalytic component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. May recruit the E2 ubiquitin-conjugating enzymes to the complex.

Synonyms:  ANAPC11,  ANAPC11p,  hANAPC11,  A0A024R8S1,  A0A087X1B5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM