DISEASES

Disease-gene associations mined from literature

Literature associating LAGE3 and lidocaine allergy

LAGE3 [ENSP00000349923]

EKC/KEOPS complex subunit LAGE3; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. LAGE3 functions as a dimerization module for the complex; Belongs to the CTAG/PCC1 family.

Synonyms:  LAGE3,  LAGE3p,  hLAGE3,  Q14657,  Q14657p ...

Linkouts:  STRING  Pharos  UniProt  OMIM