DISEASES

Disease-gene associations mined from literature

Literature associating WDR45 and alcohol-related neurodevelopmental disorder

WDR45 [ENSP00000348848]

WD repeat domain phosphoinositide-interacting protein 4; Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation . Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes . Probably recruited to membranes through its PtdIns3P activity .

Synonyms:  WDR45,  WDR45p,  hWDR45,  A0A024QYW6,  A0A024QYX1 ...

Linkouts:  STRING  Pharos  UniProt