DISEASES

Disease-gene associations mined from literature

Literature associating WNK3 and Bartter disease

WNK3 [ENSP00000346667]

Serine/threonine-protein kinase WNK3; Serine/threonine kinase which plays an important role in the regulation of electrolyte homeostasis, cell signaling, survival and proliferation. Acts as an activator and inhibitor of sodium-coupled chloride cotransporters and potassium-coupled chloride cotransporters respectively . Phosphorylates WNK4. Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their membrane expression level via a kinase-dependent pathway . Inhibits the activity of KCNJ1 by decreasing its expression at the cell membrane in a non-catalytic manner. ECO:0000269|PubMed:16357011, ECO:0000269|PubMed:16501604, ECO:0000269|PubMed:17975670, ECO:0000269|PubMed:18768590,; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WNK subfamily.

Synonyms:  WNK3,  WNK3p,  hWNK3,  A0A087WYK2,  B1AQN8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM