DISEASES

Disease-gene associations mined from literature

Literature associating TYW5 and mixed sleep apnea

TYW5 [ENSP00000346627]

tRNA wybutosine-synthesizing protein 5; tRNA hydroxylase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the hydroxylation of 7-(a- amino-a-carboxypropyl)wyosine (yW-72) into undermodified hydroxywybutosine (OHyW*). OHyW* being further transformed into hydroxywybutosine (OHyW) by LCMT2/TYW4. OHyW is a derivative of wybutosine found in higher eukaryotes; Belongs to the TYW5 family.

Synonyms:  TYW5,  TYW5p,  hTYW5,  A2RUC4,  A8KAJ9 ...

Linkouts:  STRING  Pharos  UniProt