DISEASES

Disease-gene associations mined from literature

Literature associating GPX4 and fibromyalgia

GPX4 [ENSP00000346103]

Phospholipid hydroperoxide glutathione peroxidase, mitochondrial; Protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility. Could play a major role in protecting mammals from the toxicity of ingested lipid hydroperoxides. Essential for embryonic development. Protects from radiation and oxidative damage. Essential for maturation and survival of photoreceptor cells. Plays a role in a primary T cell response to viral and parasitic infection by protecting T cells from ferroptosis, a cell death resulting from an iron-dependent accumulation of lipid reactive oxygen species, and by supporting T cell expansion; Belongs to the glutathione peroxidase family.

Synonyms:  GPX4,  GPX4p,  hGPX4,  P36969,  Q6PJX4 ...

Linkouts:  STRING  Pharos  UniProt  OMIM