Literature associating SPAM1 and Friedreich ataxia 1
SPAM1 [ENSP00000345849]
Hyaluronidase PH-20; Involved in sperm-egg adhesion. Upon fertilization sperm must first penetrate a layer of cumulus cells that surrounds the egg before reaching the zona pellucida. The cumulus cells are embedded in a matrix containing hyaluronic acid which is formed prior to ovulation. This protein aids in penetrating the layer of cumulus cells by digesting hyaluronic acid; Belongs to the glycosyl hydrolase 56 family.
Synonyms: SPAM1, SPAM1p, hSPAM1, C9J2X5, P38567 ...