DISEASES

Disease-gene associations mined from literature

Literature associating TEAD3 and skin carcinoma in situ

TEAD3 [ENSP00000345772]

Transcriptional enhancer factor TEF-5; Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to multiple functional elements of the human chorionic somatomammotropin-B gene enhancer.

Synonyms:  TEAD3,  TEAD3p,  hTEAD3,  A0A1X7SBS4,  B5MCM0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM