DISEASES

Disease-gene associations mined from literature

Literature associating CTSB and amyloidosis

CTSB [ENSP00000345672]

Cathepsin B heavy chain; Thiol protease which is believed to participate in intracellular degradation and turnover of proteins . Cleaves matrix extracellular phosphoglycoprotein MEPE . Involved in the solubilization of cross-linked TG/thyroglobulin in the thyroid follicle lumen (By similarity). Has also been implicated in tumor invasion and metastasis . ; Belongs to the peptidase C1 family. ProRule:PRU10088, ECO:0000255|PROSITE-ProRule:PRU10089,

Synonyms:  CTSB,  A0A024R374,  E9PCB3,  E9PHZ5,  E9PID0 ...

Linkouts:  STRING  Pharos  UniProt