DISEASES

Disease-gene associations mined from literature

Literature associating DHRS2 and commensal bacterial infectious disease

DHRS2 [ENSP00000344674]

Dehydrogenase/reductase SDR family member 2, mitochondrial; Displays NADPH-dependent dicarbonyl reductase activity in vitro with 3,4-Hexanedione, 2,3-Heptanedione and 1-Phenyl-1,2- propanedione as substrates. No reductase activity is displayed in vitro with steroids, retinoids and sugars as substrates. Attenuates MDM2- mediated p53/TP53 degradation, leading to p53/TP53 stabilization and increased transcription activity, resulting in the accumulation of MDM2 and CDKN1A/p21; Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Synonyms:  DHRS2,  DHRS2p,  hDHRS2,  C9JZP6,  H0YJG9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM