DISEASES

Disease-gene associations mined from literature

Literature associating NANOS3 and brain germinoma

NANOS3 [ENSP00000341992]

Nanos homolog 3; Plays a role in the maintenance of the undifferentiated state of germ cells regulating the spermatogonia cell cycle and inducing a prolonged transit in G1 phase. Affects cell proliferation probably by repressing translation of specific mRNAs. Maintains the germ cell lineage by suppressing both Bax-dependent and -independent apoptotic pathways. Essential in the early stage embryo to protect the migrating primordial germ cells (PGCs) from apoptosis.

Synonyms:  NANOS3,  NANOS3p,  hNANOS3,  P60323,  P60323p ...

Linkouts:  STRING  Pharos  UniProt  OMIM