DISEASES

Disease-gene associations mined from literature

Literature associating HNRNPA1 and autosomal dominant limb-girdle muscular dystrophy

HNRNPA1 [ENSP00000341826]

Heterogeneous nuclear ribonucleoprotein A1, N-terminally processed; Involved in the packaging of pre-mRNA into hnRNP particles, transport of poly(A) mRNA from the nucleus to the cytoplasm and may modulate splice site selection . May bind to specific miRNA hairpins . Binds to the IRES and thereby inhibits the translation of the apoptosis protease activating factor APAF1 . (Microbial infection) Cleavage by Enterovirus 71 protease 3C results in increased translation of apoptosis protease activating factor APAF1, leading to apoptosis.

Synonyms:  HNRNPA1,  HNRNPA1p,  hHNRNPA1,  A0A024RAZ7,  A0A024RB53 ...

Linkouts:  STRING  Pharos  UniProt