DISEASES

Disease-gene associations mined from literature

Literature associating SFN and pancreatic adenocarcinoma

SFN [ENSP00000340989]

14-3-3 protein sigma; Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53; Belongs to the 14-3-3 family.

Synonyms:  SFN,  P31947,  P31947p,  hP31947,  14-3-3 protein sigma ...

Linkouts:  STRING  Pharos  UniProt  OMIM