DISEASES

Disease-gene associations mined from literature

Literature associating TRPC6 and malignant hypertension

TRPC6 [ENSP00000340913]

Short transient receptor potential channel 6; Thought to form a receptor-activated non-selective calcium permeant cation channel . Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C . Seems not to be activated by intracellular calcium store depletion; Belongs to the transient receptor (TC 1.A.4) family. STrpC subfamily. TRPC6 sub-subfamily.

Synonyms:  TRPC6,  TRPC6p,  hTRPC6,  E9PJN4,  Q9Y210 ...

Linkouts:  STRING  Pharos  UniProt  OMIM