DISEASES

Disease-gene associations mined from literature

Literature associating BRAT1 and Mowat-Wilson syndrome

BRAT1 [ENSP00000339637]

BRCA1-associated ATM activator 1; Involved in DNA damage response; activates kinases ATM, SMC1A and PRKDC by modulating their phosphorylation status following ionizing radiation (IR) stress . Plays a role in regulating mitochondrial function and cell proliferation . Required for protein stability of MTOR and MTOR- related proteins, and cell cycle progress by growth factors . ECO:0000269|PubMed:22977523, ECO:0000269|PubMed:25070371,

Synonyms:  BRAT1,  BRAT1p,  hBRAT1,  F8WDN5,  Q6PJG6 ...

Linkouts:  STRING  Pharos  UniProt