DISEASES

Disease-gene associations mined from literature

Literature associating RHOG and Tangier disease

RHOG [ENSP00000339467]

Rho-related GTP-binding protein RhoG; Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB and ARHGEF26/SGEF, which induces cytoskeleton rearrangements and promotes bacterial entry. ECO:0000269|PubMed:17074883, ECO:0000269|PubMed:17875742,; Belongs to the small GTPase superfamily. Rho family.

Synonyms:  RHOG,  ARHG,  P84095,  Q6ICQ8,  P84095p ...

Linkouts:  STRING  Pharos  UniProt  OMIM