DISEASES

Disease-gene associations mined from literature

Literature associating CDK10 and syndactyly-telecanthus-anogenital and renal malformations syndrome

CDK10 [ENSP00000338673]

Cyclin-dependent kinase 10; Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells) . Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling ; Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.

Synonyms:  CDK10,  CDK10p,  hCDK10,  D6RA59,  D6REZ2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM