DISEASES

Disease-gene associations mined from literature

Literature associating SEC62 and hereditary lymphedema I

SEC62 [ENSP00000337688]

Translocation protein SEC62; Mediates post-translational transport of precursor polypeptides across endoplasmic reticulum (ER). Proposed to act as a targeting receptor for small presecretory proteins containing short and apolar signal peptides. Targets and properly positions newly synthesized presecretory proteins into the SEC61 channel-forming translocon complex, triggering channel opening for polypeptide translocation to the ER lumen.

Synonyms:  SEC62,  SEC62p,  hSEC62,  F8WCJ7,  F8WDG8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM