DISEASES

Disease-gene associations mined from literature

Literature associating CENPQ and CREST syndrome

CENPQ [ENSP00000337289]

Centromere protein Q; Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex . Plays an important role in chromosome congression and in the recruitment of CENP-O complex (which comprises CENPO, CENPP, CENPQ and CENPU), CENPE and PLK1 to the kinetochores . ; Belongs to the CENP-Q/OKP1 family.

Synonyms:  CENPQ,  Q7L2Z9,  Q7L2Z9p,  hQ7L2Z9,  55166 ...

Linkouts:  STRING  Pharos  UniProt  OMIM