DISEASES

Disease-gene associations mined from literature

Literature associating SPNS2 and sensorineural hearing loss

SPNS2 [ENSP00000333292]

Protein spinster homolog 2; Acts a a crucial lysosphingolipid sphingosine 1-phosphate (S1P) transporter involved in S1P secretion and function . S1P is a bioactive signaling molecule that regulates many physiological processes important for the development and for the immune system. Regulates levels of S1P and the S1P gradient that exists between the high circulating concentrations of S1P and low tissue levels that control lymphocyte trafficking .

Synonyms:  SPNS2,  SPNS2p,  hSPNS2,  I3L4N9,  Q8IVW8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM