DISEASES

Disease-gene associations mined from literature

Literature associating CASP9 and thoracic cancer

CASP9 [ENSP00000330237]

Caspase-9 subunit p10; Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP); Belongs to the peptidase C14A family.

Synonyms:  CASP9,  CASP9p,  hCASP9,  A0A087WX72,  F8VVS7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM