DISEASES

Disease-gene associations mined from literature

Literature associating CREB3L2 and meninges sarcoma

CREB3L2 [ENSP00000329140]

Processed cyclic AMP-responsive element-binding protein 3-like protein 2; Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic reticulum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in chondrogenesis by activating the transcription of SEC23A, which promotes the transport and secretion of cartilage matrix proteins, and possibly that of ER biogenesis-related genes (By similarity). In a neuroblastoma cell line, protects cells from ER stress-induced death . In vitro activates transcription of target genes via direct binding to the CRE site .

Synonyms:  CREB3L2,  CREB3L2p,  hCREB3L2,  A0A087WU77,  A0A087WUP1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM