Literature associating TRIM50 and Williams-Beuren syndrome
TRIM50 [ENSP00000327994]
E3 ubiquitin-protein ligase TRIM50; E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction; Belongs to the TRIM/RBCC family.
Synonyms: TRIM50, TRIM50p, hTRIM50, Q2M204, Q86XT4 ...