DISEASES

Disease-gene associations mined from literature

Literature associating TGIF1 and ascending cholangitis

TGIF1 [ENSP00000327959]

Homeobox protein TGIF1; Binds to a retinoid X receptor (RXR) responsive element from the cellular retinol-binding protein II promoter (CRBPII-RXRE). Inhibits the 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element. Active transcriptional corepressor of SMAD2. Links the nodal signaling pathway to the bifurcation of the forebrain and the establishment of ventral midline structures. May participate in the transmission of nuclear signals during development and in the adult, as illustrated by the down-modulation of the RXR alpha activities; Belongs to the TALE/TGIF homeobox family.

Synonyms:  TGIF1,  TGIF1p,  hTGIF1,  F8VUY0,  F8VVS9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM