DISEASES

Disease-gene associations mined from literature

Literature associating NKX2-5 and ovarian endodermal sinus tumor

NKX2-5 [ENSP00000327758]

Homeobox protein Nkx-2.5; Implicated in commitment to and/or differentiation of the myocardial lineage. Acts as a transcriptional activator of ANF in cooperation with GATA4 (By similarity). Binds to the core DNA motif of NPPA promoter . It is transcriptionally controlled by PBX1 and acts as a transcriptional repressor of CDKN2B (By similarity). It is required for spleen development. ECO:0000269|PubMed:22560297, ECO:0000269|PubMed:22849347,

Synonyms:  NKX2-5,  A0A0S2Z383,  A0A0S2Z3K2,  E5RH49,  P52952 ...

Linkouts:  STRING  Pharos  UniProt