DISEASES

Disease-gene associations mined from literature

Literature associating TACC3 and Wolf-Hirschhorn syndrome

TACC3 [ENSP00000326550]

Transforming acidic coiled-coil-containing protein 3; Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors (By similarity). Acts as component of the TACC3/ch- TOG/clathrin complex proposed to contribute to stabilization of kinetochore fibers of the mitotic spindle by acting as inter- microtubule bridge. The TACC3/ch-TOG/clathrin complex is required for the maintenance of kinetochore fiber tension (PubMed:21297582, PubMed:23532825). May be involved in the control of cell growth and differentiation. May contribute to cancer .

Synonyms:  TACC3,  TACC3p,  hTACC3,  A0A494BZT8,  A0A494C117 ...

Linkouts:  STRING  Pharos  UniProt  OMIM