Literature associating PARL and hereditary spastic paraplegia 7
PARL [ENSP00000325421]
Presenilins-associated rhomboid-like protein, mitochondrial; Required for the control of apoptosis during postnatal growth. Essential for proteolytic processing of an antiapoptotic form of OPA1 which prevents the release of mitochondrial cytochrome c in response to intrinsic apoptotic signals (By similarity). Required for the maturation of PINK1 into its 52kDa mature form after its cleavage by mitochondrial-processing peptidase (MPP) . Promotes changes in mitochondria morphology regulated by phosphorylation of P- beta domain .
Synonyms: PARL, A0A1W2PP66, A0A1W2PS40, C9JNP8, F8WCQ4 ...