DISEASES

Disease-gene associations mined from literature

Literature associating CYP2B6 and retinitis pigmentosa 56

CYP2B6 [ENSP00000324648]

Cytochrome P450 2B6; A cytochrome P450 monooxygenase involved in the metabolism of endocannabinoids and steroids . Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH-- hemoprotein reductase). Catalyzes the epoxidation of double bonds of arachidonoylethanolamide (anandamide) to 8,9-, 11,12-, and 14,15- epoxyeicosatrienoic acid ethanolamides (EpETrE-EAs), potentially modulating endocannabinoid system signaling . Hydroxylates steroid hormones, including testosterone at C-16 and estrogens at C-2 . Plays a role in the oxidative metabolism of xenobiotics, including plant lipids and drugs . Acts as a 1,4-cineole 2-exo- monooxygenase . ECO:0000269|PubMed:12865317, ECO:0000269|PubMed:21289075,

Synonyms:  CYP2B6,  CYP2B6p,  hCYP2B6,  A0A2R8YFA4,  M0QZJ2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM