DISEASES

Disease-gene associations mined from literature

Literature associating GLYR1 and retinitis pigmentosa 20

GLYR1 [ENSP00000322716]

Putative oxidoreductase GLYR1; Nucleosome-destabilizing factor that is recruited to genes during transcriptional activation . Facilitates Pol II transcription through nucleosomes . Binds DNA (in vitro) . Recognizes and binds trimethylated 'Lys-36' of histone H3 (H3K36me3) . Promotes KDM1B demethylase activity . Stimulates the acetylation of 'Lys-56' of nucleosomal histone H3 (H3K56ac) by EP300 . Regulates p38 MAP kinase activity by mediating stress activation of p38alpha/MAPK14 and specifically regulating MAPK14 signaling . Indirectly promotes phosphorylation of MAPK14 and activation of ATF2 . The phosphorylation of MAPK14 requires upstream activity of MAP2K4 and MAP2K6 . Putative oxidoreductase . ; Belongs to the HIBADH-related family. NP60 subfamily.

Synonyms:  GLYR1,  GLYR1p,  hGLYR1,  K7EK70,  K7ELL0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM