DISEASES

Disease-gene associations mined from literature

Literature associating TUFM and avian influenza

TUFM [ENSP00000322439]

Elongation factor Tu, mitochondrial; Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG- I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.

Synonyms:  TUFM,  A0A384ME17,  H3BNU3,  P49411,  H3BNU3p ...

Linkouts:  STRING  Pharos  UniProt  OMIM