DISEASES

Disease-gene associations mined from literature

Literature associating TUBB3 and refractive error

TUBB3 [ENSP00000320295]

Tubulin beta-3 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. TUBB3 plays a critical role in proper axon guidance and mantainance. Binding of NTN1/Netrin-1 to its receptor UNC5C might cause dissociation of UNC5C from polymerized TUBB3 in microtubules and thereby lead to increased microtubule dynamics and axon repulsion . Plays a role in dorsal root ganglion axon projection towards the spinal cord .

Synonyms:  TUBB3,  TUBB3p,  hTUBB3,  G3V2A3,  G3V2N6 ...

Linkouts:  STRING  Pharos  UniProt