Literature associating FRMD8 and palmoplantar keratoderma-esophageal carcinoma syndrome
FRMD8 [ENSP00000319726]
FERM domain-containing protein 8; Promotes the cell surface stability of iRhom1/RHBDF1 and iRhom2/RHBDF2 and prevents their degradation via the endolysosomal pathway. By acting on iRhoms, involved in ADAM17-mediated shedding of TNF, amphiregulin/AREG, HBEGF and TGFA from the cell surface . Negatively regulates Wnt signaling, possibly by antagonizing the recruitment of AXIN1 to LRP6 .
Synonyms: FRMD8, FRMD8p, hFRMD8, E9PRA3, E9PRP1 ...