DISEASES

Disease-gene associations mined from literature

Literature associating TRAF7 and sphenoorbital meningioma

TRAF7 [ENSP00000318944]

E3 ubiquitin-protein ligase TRAF7; E3 ubiquitin ligase capable of auto-ubiquitination, following phosphorylation by MAP3K3. Potentiates MAP3K3-mediated activation of the NF-kappa-B, JUN/AP1 and DDIT3 transcriptional regulators . Induces apoptosis when overexpressed . Plays a role in the phosphorylation of MAPK1 and/or MAPK3, probably via its interaction with MAP3K3.

Synonyms:  TRAF7,  TRAF7p,  hTRAF7,  A0A087WUB0,  H3BR17 ...

Linkouts:  STRING  Pharos  UniProt  OMIM