DISEASES

Disease-gene associations mined from literature

Literature associating CHAF1B and acute megakaryocytic leukemia

CHAF1B [ENSP00000315700]

Chromatin assembly factor 1 subunit B; Complex that is thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. ; Belongs to the WD repeat HIR1 family.

Synonyms:  CHAF1B,  CHAF1Bp,  hCHAF1B,  Q13112,  Q13112p ...

Linkouts:  STRING  Pharos  UniProt  OMIM