DISEASES

Disease-gene associations mined from literature

Literature associating CD209 and severe acute respiratory syndrome

CD209 [ENSP00000315477]

CD209 antigen; Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response. (Microbial infection) Acts as an attachment receptor for HIV- 1 and HIV-2. (Microbial infection) Acts as an attachment receptor for Cytomegalovirus. (Microbial infection) Acts as an attachment receptor for Dengue virus. (Microbial infection) Acts as an attachment receptor for Herpes simplex virus 1. (Microbial infection) Acts as an attachment receptor for SARS coronavirus. (Microbial infection) Acts as an attachment receptor for Lassa virus . Acts as an attachment receptor for Marburg virusn. (Microbial infection) Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus. (Microbial infection) Probably recognizes in a calcium- dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA . Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule .

Synonyms:  CD209,  CD209p,  hCD209,  M0QZG5,  M0R0P0 ...

Linkouts:  STRING  Pharos  UniProt  OMIM