DISEASES

Disease-gene associations mined from literature

Literature associating ANGPT2 and retinopathy of prematurity

ANGPT2 [ENSP00000314897]

Angiopoietin-2; Binds to TEK/TIE2, competing for the ANGPT1 binding site, and modulating ANGPT1 signaling. Can induce tyrosine phosphorylation of TEK/TIE2 in the absence of ANGPT1. In the absence of angiogenic inducers, such as VEGF, ANGPT2-mediated loosening of cell-matrix contacts may induce endothelial cell apoptosis with consequent vascular regression. In concert with VEGF, it may facilitate endothelial cell migration and proliferation, thus serving as a permissive angiogenic signal.

Synonyms:  ANGPT2,  ANGPT2p,  hANGPT2,  E7EVQ3,  O15123 ...

Linkouts:  STRING  Pharos  UniProt  OMIM