DISEASES

Disease-gene associations mined from literature

Literature associating TFE3 and kidney benign neoplasm

TFE3 [ENSP00000314129]

Transcription factor E3; Transcription factor that specifically recognizes and binds E-box sequences (5'-CANNTG-3') (By similarity). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer . It also binds very well to a USF/MLTF site . May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 .

Synonyms:  TFE3,  TFE3p,  hTFE3,  A0A024QZ23,  P19532 ...

Linkouts:  STRING  Pharos  UniProt  OMIM