DISEASES

Disease-gene associations mined from literature

Literature associating CD46 and necrotizing fasciitis

CD46 [ENSP00000313875]

Membrane cofactor protein; Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. (Microbial infection) Acts as a receptor for Adenovirus subgroup B2 and Ad3. ECO:0000269|PubMed:14566335, ECO:0000269|PubMed:15047806, ECO:0000269|PubMed:15078926, ECO:0000269|PubMed:15919905, (Microbial infection) Acts as a receptor for Herpesvirus 6/HHV-6.

Synonyms:  CD46,  CD46p,  hCD46,  P15529,  R4GN18 ...

Linkouts:  STRING  Pharos  UniProt  OMIM