Literature associating CCDC65 and primary ciliary dyskinesia 8
CCDC65 [ENSP00000312706]
Dynein regulatory complex subunit 2; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes (By similarity). Plays a critical role in the assembly of N-DRC and also stabilizes the assembly of multiple inner dynein arms and radial spokes. Coassembles with DRC1 to form a central scaffold needed for assembly of the N-DRC and its attachment to the outer doublet microtubules . ; Belongs to the DRC2 family.
Synonyms: CCDC65, CCDC65p, hCCDC65, F8VR42, F8W0R6 ...