DISEASES

Disease-gene associations mined from literature

Literature associating TPMT and drug allergy

TPMT [ENSP00000312304]

Thiopurine S-methyltransferase; Catalyzes the S-methylation of thiopurine drugs such as 6- mercaptopurine (also called mercaptopurine, 6-MP or its brand name Purinethol) and 6-thioguanine (also called tioguanine or 6-TG) using S- adenosyl-L-methionine as the methyl donor (PubMed:657528, PubMed:18484748). TPMT activity modulates the cytotoxic effects of thiopurine prodrugs. A natural substrate for this enzyme has yet to be identified; Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.

Synonyms:  TPMT,  A0A024QZW0,  P51580,  P51580p,  hP51580 ...

Linkouts:  STRING  Pharos  UniProt  OMIM