DISEASES

Disease-gene associations mined from literature

Literature associating PSMA8 and pelvic varices

PSMA8 [ENSP00000311121]

Proteasome subunit alpha-type 8; Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complexe that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I.

Synonyms:  PSMA8,  PSMA8p,  hPSMA8,  A0A087WYS6,  F5GY34 ...

Linkouts:  STRING  Pharos  UniProt