DISEASES

Disease-gene associations mined from literature

Literature associating PPARD and abdominal obesity-metabolic syndrome 1

PPARD [ENSP00000310928]

Peroxisome proliferator-activated receptor delta; Ligand-activated transcription factor. Receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Has a preference for poly-unsaturated fatty acids, such as gamma- linoleic acid and eicosapentanoic acid. Once activated by a ligand, the receptor binds to promoter elements of target genes. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the acyl-CoA oxidase gene. Decreases expression of NPC1L1 once activated by a ligand. ; Belongs to the nuclear hormone receptor family. NR1 subfamily.

Synonyms:  PPARD,  A0A024RCW6,  F1D8S7,  NR1C2,  Q03181 ...

Linkouts:  STRING  Pharos  UniProt  OMIM