DISEASES

Disease-gene associations mined from literature

Literature associating LIME1 and glycogen storage disease I

LIME1 [ENSP00000309521]

Lck-interacting transmembrane adapter 1; Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4- mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.

Synonyms:  LIME1,  LIME1p,  hLIME1,  A0A087WT39,  A0A087WUJ1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM