DISEASES

Disease-gene associations mined from literature

Literature associating MLLT10 and discrete subaortic stenosis

MLLT10 [ENSP00000307411]

Protein AF-10; Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation .

Synonyms:  MLLT10,  MLLT10p,  hMLLT10,  A0A494C038,  A0A494C093 ...

Linkouts:  STRING  Pharos  UniProt  OMIM