DISEASES

Disease-gene associations mined from literature

Literature associating IL16 and atopic dermatitis

IL16 [ENSP00000302935]

Pro-interleukin-16; Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4. Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA- binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.

Synonyms:  IL16,  IL16p,  hIL16,  H0YKB7,  H0YLB1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM