DISEASES

Disease-gene associations mined from literature

Literature associating MGMT and pituitary carcinoma

MGMT [ENSP00000302111]

Methylated-DNA--protein-cysteine methyltransferase; Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated; Belongs to the MGMT family.

Synonyms:  MGMT,  B4DEE8,  P16455,  B4DEE8p,  hB4DEE8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM