DISEASES

Disease-gene associations mined from literature

Literature associating PLAAT5 and Poland syndrome

PLAAT5 [ENSP00000301790]

Phospholipase A and acyltransferase 5; Exhibits both phospholipase A1/2 and acyltransferase activities . Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids . Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19000777, PubMed:22825852).

Synonyms:  PLAAT5,  PLAAT5p,  hPLAAT5,  F5H4Q3,  H0YGT7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM