DISEASES

Disease-gene associations mined from literature

Literature associating UBXN6 and multisystem proteinopathy

UBXN6 [ENSP00000301281]

UBX domain-containing protein 6; May negatively regulate the ATPase activity of VCP, an ATP- driven segregase that associates with different cofactors to control a wide variety of cellular processes . As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation . It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins . Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes . ECO:0000269|PubMed:23335559, ECO:0000269|PubMed:26475856,

Synonyms:  UBXN6,  UBXN6p,  hUBXN6,  K7EJ02,  K7ELN1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM