DISEASES

Disease-gene associations mined from literature

Literature associating CYP2A6 and substance dependence

CYP2A6 [ENSP00000301141]

Cytochrome P450 2A6; Exhibits a high coumarin 7-hydroxylase activity. Can act in the hydroxylation of the anti-cancer drugs cyclophosphamide and ifosphamide. Competent in the metabolic activation of aflatoxin B1. Constitutes the major nicotine C-oxidase. Acts as a 1,4-cineole 2-exo- monooxygenase. Possesses low phenacetin O-deethylation activity. ECO:0000269|PubMed:17125252, ECO:0000269|PubMed:18779312,

Synonyms:  CYP2A6,  CYP2A6p,  hCYP2A6,  M0R2Z4,  P11509 ...

Linkouts:  STRING  Pharos  UniProt