DISEASES

Disease-gene associations mined from literature

Literature associating CHP2 and liver cancer

CHP2 [ENSP00000300113]

Calcineurin B homologous protein 2; Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Binds to and activates SLC9A1/NHE1 in a serum-independent manner, thus increasing pH and protecting cells from serum deprivation-induced death. Also plays a role in the regulation of cell proliferation and tumor growth by increasing the phosphatase activity of PPP3CA in a calcium-dependent manner. Activator of the calcineurin/NFAT signaling pathway. Involved in the cytoplasmic translocation of the transcription factor NFATC3 to the nucleus; Belongs to the calcineurin regulatory subunit family. CHP subfamily.

Synonyms:  CHP2p,  hCHP2,  O43745,  O43745p,  hO43745 ...

Linkouts:  STRING  Pharos  UniProt